Ott O, Stillkrieg W, Lambrecht U, Sauer TO, Schweizer C, Lamrani A, Strnad V, Hack C, Beckmann M, Uder M, Fietkau R, Distel L (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 14
Journal Issue: 14
Simple Summary Accelerated partial breast irradiation represents a well-established and safe treatment alternative for selected patients with early stage breast cancer after breast-conserving surgery. In a prospective trial on external beam partial breast irradiation, the risk for radiogenic pneumonitis is analyzed. After a median follow-up of 56 (1-129) months, radiogenic pneumonitis grade 2 appeared in only 1/170 (0.6%) patients. Compared to standard whole breast irradiation, the radiation doses applied to the lungs were very low. The patient with the radiogenic pneumonitis was found to have a generally increased radiation susceptibility. Using accelerated partial breast irradiation, the risk of radiogenic pneumonitis appeared quite low and may be limited to very exceptional cases associated with innate risk factors with an increased radiation susceptibility. In order to evaluate the risk for radiation-associated symptomatic pneumonitis in a prospective external beam accelerated partial breast irradiation (APBI) trial, between 2011 and 2021, 170 patients with early stage breast cancer were enclosed in the trial. Patients were eligible for study participation if they had a histologically confirmed breast cancer or an exclusive ductal carcinoma in situ (DCIS), a tumor size <= 3 cm, free safety margins >= 2 mm, no involved axillary lymph nodes, tumor bed clips, and were >= 50 years old. Patients received APBI with 38 Gy with 10 fractions in 10 consecutive working days. The trial was registered at the German Clinical Trials Registry, DRKS-ID: DRKS00004417. Median follow-up was 56 (1-129) months. Ipsilateral lung MLD, V20, and V30 were 4.3 +/- 1.4 Gy, 3.0 +/- 2.0%, and 1.0 +/- 1.0%, respectively. Radiogenic pneumonitis grade 2 appeared in 1/170 (0.6%) patients two months after radiotherapy. Ipsilateral MLD, V20, and V30 were 6.1 Gy, 7, and 3% in this patient. Additionally, individual radiosensitivity was increased in this specific patient. Compared to WBI, APBI leads to lower lung doses. Using APBI, the risk of symptomatic radiogenic pneumonitis is very low and may be limited, with an ipsilateral V20 < 3% to very exceptional cases associated with innate risk factors with an increased radiation susceptibility.
APA:
Ott, O., Stillkrieg, W., Lambrecht, U., Sauer, T.-O., Schweizer, C., Lamrani, A.,... Distel, L. (2022). External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis. Cancers, 14(14). https://dx.doi.org/10.3390/cancers14143520
MLA:
Ott, Oliver, et al. "External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis." Cancers 14.14 (2022).
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