Multifrequency Investigation of Single-and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors

Weisenstein C, Richter M, Wigger AK, Boßerhoff AK, Bolivar PH (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Biosensors MDPI

Book Volume: 12

Article Number: 483

Journal Issue: 7

DOI: 10.3390/bios12070483

Abstract

Due to the occurrence of THz-excited vibrational modes in biomacromolecules, the THz frequency range has been identified as particularly suitable for developing and applying new bio-analytical methods. We present a scalable THz metamaterial-based biosensor being utilized for the multifrequency investigation of single-and double-stranded DNA (ssDNA and dsDNA) samples. It is demonstrated that the metamaterial resonance frequency shift by the DNA’s presence depends on frequency. Our experiments with the scalable THz biosensors demonstrate a major change in the degree of the power function for dsDNA by 1.53 ± 0.06 and, in comparison, 0.34 ± 0.11 for ssDNA as a function of metamaterial resonance frequency. Thus, there is a significant advantage for dsDNA detection that can be used for increased sensitivity of biomolecular detection at higher frequencies. This work represents a first step for application-specific biosensors with potential advantages in sensitivity, specificity, and robustness.

Authors with CRIS profile

Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Universität Siegen DE Germany (DE)

How to cite

APA:

Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2022). Multifrequency Investigation of Single-and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors. Biosensors, 12(7). https://dx.doi.org/10.3390/bios12070483

MLA:

Weisenstein, Christian, et al. "Multifrequency Investigation of Single-and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors." Biosensors 12.7 (2022).

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