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ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma

Spangler B, Kappelmann M, Schittek B, Meierjohann S, Vardimon L, Bosserhoff AK, Kuphal S (2012)

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Publication Type: Journal article

Publication year: 2012

Journal

Book Volume: 130

Pages Range: 2801-2811

Journal Issue: 12

DOI: 10.1002/ijc.26277

Abstract

Recently, we discovered that the loss of E-cadherin induces c-Jun protein expression, which is a member of the AP-1 transcription factor family and a key player in the processes of cell proliferation and tumor development and also found in elevated levels in melanomas. Notably, the mRNA level of c-Jun was not affected, suggesting that c-Jun is regulated at post-transcriptional level. Here, we present data that suggest that the dynamic cytoskeletal network, linked to E-cadherin, is involved in the regulation of the c-Jun protein and transcriptional activity. In a signaling cascade, the loss of E-cadherin activates the transcriptional regulator ETS-1 and consequently leads to the induction of RhoC expression that stabilizes c-Jun in melanoma. The link between RhoC and c-Jun seems to be indirect via the cytoskeleton. We conclude that the loss of E-cadherin mediated cell-adhesion induces c-Jun protein expression in a multistep process, offering several possibilities for therapeutic intervention. Copyright © 2011 UICC.

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How to cite

APA:

Spangler, B., Kappelmann, M., Schittek, B., Meierjohann, S., Vardimon, L., Bosserhoff, A.K., & Kuphal, S. (2012). ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma. International Journal of Cancer, 130(12), 2801-2811. https://doi.org/10.1002/ijc.26277

MLA:

Spangler, Barbara, et al. "ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma." International Journal of Cancer 130.12 (2012): 2801-2811.

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