E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma
Kuphal S, Bosserhoff AK (2012)
Publication Type: Journal article, Review article
Publication year: 2012
Journal
Book Volume: 524
Pages Range: 43-47
Journal Issue: 1
DOI: 10.1016/j.abb.2011.10.020
Abstract
Cell-cell communication is necessary for the crosstalk between cells that constitute multicellular organisms and is essential for cells to coordinate their physiological behavior to create cohesive tissues. Cellular crosstalk is not only controlled by molecules, like growth factors, hormones, ions and G-proteins, etc. but also by cell-cell contacts. These contacts are essential for intercellular communication and are involved in survival, apoptosis, proliferation, differentiation and homeostasis of entire tissues. In polarized epithelia of vertebrates, the adherent junction is part of the tripartite junctional complex that is localized at the juxtaluminal region, which includes tight junctions (including claudins, occludins, and zonula occludens proteins), desmosomal junctions (including desmogleins), and adherent junctions. In focus of the manuscript are adherent molecules of the cadherin superfamily of the skin. In the normal epidermis, melanocytes and keratinocytes are mostly connected via E-cadherin, P-cadherin and H-cadherin [1-3]. Melanocytes that reside in the basal layer of the epidermis predominantly contain E-cadherin and H-cadherin, whereas those that reside in the hair follicles are rich in P-cadherin [2]. The regulation and role of E-cadherin during melanoma development will be the focus of this review. © 2012 Elsevier Ltd. All rights reserved.
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Germany (DE)How to cite
APA:
Kuphal, S., & Bosserhoff, A.K. (2012). E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma. Archives of Biochemistry and Biophysics, 524(1), 43-47. https://dx.doi.org/10.1016/j.abb.2011.10.020
MLA:
Kuphal, Silke, and Anja Katrin Bosserhoff. "E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma." Archives of Biochemistry and Biophysics 524.1 (2012): 43-47.
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