Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method

El-Rashidy AA, Waly G, Gad A, Hashem AA, Balasubramanian P, Kaya S, Boccaccini AR, Sami I (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of Non-Crystalline Solids Elsevier

Book Volume: 483

Pages Range: 26-36

DOI: 10.1016/j.jnoncrysol.2017.12.044

Abstract

The study aimed at preparing Ag-doped bioactive glass (BG) nanoparticles containing 5 wt% Ag2O using a new modified Stöber method (Ag-BGm) and the conventional sol-gel method (Ag-BGsg). The aim of employing the new Ag-doping mechanism is to implement a relatively short process to incorporate higher concentration of silver (Ag+) ions in an attempt to combine the antibacterial activity of silver with the bioactivity of BG. SEM and TEM micrographs showed that Ag-BGm nanoparticles were mondispersed, and spherical, while Ag-BGsg nanoparticles were formed of highly porous irregular agglomerated particles. A significantly higher silicon, calcium and silver ions release from the Ag-BGsg was evident, as compared to Ag-BGm, in deionized water (DIW). In vitro bioactivity test showed rapid bioactive properties of Ag-BGsg in simulated body fluid (SBF), as compared to Ag-BGm. Both BGs showed antibacterial effect against E. coli O157: H7 wild type strain 93111 and S. aureus ATCC 25923 as evident by the disc diffusion assay, but Ag-BGsg showed significantly higher mean inhibition zone compared to Ag-BGm. It may be concluded that both Ag-BGsg and Ag-BGm has the potential to be used as bone substitute materials with the Ag-BGsg being more promising due to its high bioactivity and antibacterial effect.

Authors with CRIS profile

Preethi Balasubramanian Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Seray Schmitz Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Cairo University EG Egypt (EG)

How to cite

APA:

El-Rashidy, A.A., Waly, G., Gad, A., Hashem, A.A., Balasubramanian, P., Kaya, S.,... Sami, I. (2018). Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method. Journal of Non-Crystalline Solids, 483, 26-36. https://dx.doi.org/10.1016/j.jnoncrysol.2017.12.044

MLA:

El-Rashidy, Aiah A., et al. "Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method." Journal of Non-Crystalline Solids 483 (2018): 26-36.

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