Risk-Adjusted Cancer Screening and Prevention (RiskAP): complementing screening for early disease detection by a learning screening based on risk factor

Schmutzler RK, Schmitz-Luhn B, Borisch B, Devilee P, Eccles D, Hall P, Balmaña J, Boccia S, Dabrock P, Emons G, Gaissmaier W, Gronwald J, Houwaart S, Huster S, Kast K, Katalinic A, Linn SC, Matthijs G, Moorthie S, Pharoah P, Rhiem K, Spranger T, Stoppa-Lyonnet D, Van Delden JJM, van den Bulcke M, Woopen C (2021)

Publication Language: German

Publication Type: Journal article, Original article

Publication year: 2021

Journal

Book Volume: 16

DOI: 10.1159/000517182

Abstract

Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept.

Authors with CRIS profile

Involved external institutions

Ruhr-Universität Bochum (RUB) Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Universität zu Lübeck Germany (DE) Leiden University Medical Center Netherlands (NL) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron Spain (ES) Universitätsklinikum Göttingen Germany (DE) Universiteit Utrecht (UU) / Utrecht University Netherlands (NL) Netherlands Cancer Institute (NKI) Netherlands (NL) Universität Konstanz Germany (DE) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Italy (IT) University of Geneva / Université de Genève (UNIGE) Switzerland (CH) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Universitätsklinikum Köln Germany (DE) University of Cambridge United Kingdom (GB) Karolinska Institute Sweden (SE) BRCA-Netzwerk e.V. Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) University of Southampton United Kingdom (GB) Universität zu Köln Germany (DE) University of Paris 5 - René Descartes / Université Paris V René Descartes France (FR)

How to cite

APA:

Schmutzler, R.K., Schmitz-Luhn, B., Borisch, B., Devilee, P., Eccles, D., Hall, P.,... Woopen, C. (2021). Risk-Adjusted Cancer Screening and Prevention (RiskAP): complementing screening for early disease detection by a learning screening based on risk factor. Breast Care, 16. https://dx.doi.org/10.1159/000517182

MLA:

Schmutzler, Rita Katharina, et al. "Risk-Adjusted Cancer Screening and Prevention (RiskAP): complementing screening for early disease detection by a learning screening based on risk factor." Breast Care 16 (2021).

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