An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research

An R, Strissel P, Al-Abboodi M, Robering JW, Reakasame S, Eckstein M, Peddi A, Hauck T, Bäuerle T, Boccaccini AR, Youssef A, Sun J, Strick R, Horch RE, Boos A, Kengelbach-Weigand A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Bioengineering MDPI

Book Volume: 9

Article Number: 280

Journal Issue: 7

DOI: 10.3390/bioengineering9070280

Abstract

Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism. Alginate–fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based on its stability and biocompatibility. We propose that the novel tumor model may not only serve as an invaluable platform for analyzing and understanding the molecular mechanisms and pattern of oncologic diseases, but also be tailored for individual therapy via transplantation of breast cancer patient-derived tumors.

Authors with CRIS profile

Ran An Professur für Plastische Chirurgie und Handchirurgie Pamela Strissel Medizinische Fakultät Majida Al-Abboodi Professur für Plastische Chirurgie und Handchirurgie Jan Willem Robering Lehrstuhl für Biophysik Supachai Reakasame Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Markus Eckstein Institute of Pathology Theresa Promny Department of Plastic and Hand Surgery Tobias Bäuerle Professur für Multimodale Bildgebung in der präklinischen Forschung Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Reiner Strick Medizinische Fakultät Raymund Horch Professur für Plastische Chirurgie und Handchirurgie Anja Boos Department of Plastic and Hand Surgery Annika Kengelbach-Weigand Department of Plastic and Hand Surgery

Involved external institutions

Tongji Medical College (TJMC) / 同济医学院 CN China (CN) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

An, R., Strissel, P., Al-Abboodi, M., Robering, J.W., Reakasame, S., Eckstein, M.,... Kengelbach-Weigand, A. (2022). An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research. Bioengineering, 9(7). https://doi.org/10.3390/bioengineering9070280

MLA:

An, Ran, et al. "An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research." Bioengineering 9.7 (2022).

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