A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics
Werner P, Burger M, Frank F, Garcke H (2022)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2022
Journal
Book Volume: 3
Pages Range: 1091-1112
Journal Issue: 82
DOI: 10.1137/21m1433642
Abstract
The aim of this paper is to develop suitable models for the phenomenon of cell blebbing, which allow for computational predictions of mechanical effects, including the crucial interaction of the cell membrane and the actin cortex. For this sake, we resort to a two-phase field model that uses diffuse descriptions of both the membrane and the cortex, which in particular allows for a suitable description of the interaction via linker protein densities. Besides the detailed modeling, we discuss some energetic aspects of the models and present a numerical scheme, which allows us to carry out several computational studies. In those, we demonstrate that several effects found in experiments can be reproduced, in particular, bleb formation by cortex rupture, which was not possible by previous models without the linker dynamics.
Authors with CRIS profile
Philipp Werner
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Martin Burger
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Florian Frank
Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)
Involved external institutions
Germany (DE)How to cite
APA:
Werner, P., Burger, M., Frank, F., & Garcke, H. (2022). A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics. SIAM Journal on Applied Mathematics, 3(82), 1091-1112. https://dx.doi.org/10.1137/21m1433642
MLA:
Werner, Philipp, et al. "A diffuse interface model for cell blebbing including membrane-cortex coupling with linker dynamics." SIAM Journal on Applied Mathematics 3.82 (2022): 1091-1112.
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