Environmentally friendly fabrication of electrospun nanofibers made of polycaprolactone, chitosan and k-carrageenan (PCL/CS/k-C)

Vargas Osorio Z, Ruther F, Chen S, Sengupta S, Liverani L, Michalek M, Galusek D, Boccaccini AR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Biomedical Materials Institute of Physics: Hybrid Open Access

Book Volume: 17

Journal Issue: 4

DOI: 10.1088/1748-605X/ac6eaa

Abstract

Electrospun fibers based on biodegradable polyanionic or polycationic biopolymers are highly beneficial for biomedical applications. In this work, electrospun nanofibers made from poly(epsilon caprolactone) (PCL), chitosan (CS) and k-carrageenan (k-C) were successfully fabricated using several mixtures of benign solvents containing formic acid and acetic acid. The addition of k-C improved the preparation procedure for the production of PCL/CS fibers by electrospinning. Moreover, a polymer mixture was selected to be stored at -20 degrees C for one month with the purpose to study the properties of the resulting fiber mat. The results indicated that fiber characteristics were not seriously compromised compared to the ones of those fabricated with the original solution, which represents an important reduction in produced waste. Thus, the interactions that occur between positively and negatively charged hydrophilic polysaccharides might induce higher stability to the linear aliphatic polyester in the polymer mixture. All fiber mats were morphologically, physico-chemically and mechanically characterized, showing average fiber diameters in the nano scale. A direct cell viability assay using ST-2 cells demonstrated cell proliferation after seven days of incubation for all prepared fiber mats, confirming their suitability as potential candidates for bone tissue engineering and wound healing applications.

Authors with CRIS profile

Zulema Vargas Osorio Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Florian Ruther Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Trenčianska univerzita Alexandra Dubčeka v Trenčíne SK Slovakia (SK)

How to cite

APA:

Vargas Osorio, Z., Ruther, F., Chen, S., Sengupta, S., Liverani, L., Michalek, M.,... Boccaccini, A.R. (2022). Environmentally friendly fabrication of electrospun nanofibers made of polycaprolactone, chitosan and k-carrageenan (PCL/CS/k-C). Biomedical Materials, 17(4). https://dx.doi.org/10.1088/1748-605X/ac6eaa

MLA:

Vargas Osorio, Zulema, et al. "Environmentally friendly fabrication of electrospun nanofibers made of polycaprolactone, chitosan and k-carrageenan (PCL/CS/k-C)." Biomedical Materials 17.4 (2022).

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