Application of microfluidic chips in anticancer drug screening
Fan XY, Deng ZF, Yan YY, E Orel V, Shypko A, B Orel V, Ivanova D, Pilarsky C, Tang J, Chen ZS, Zhang JY (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 22
Pages Range: 302-314
Journal Issue: 3
Abstract
With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.
Authors with CRIS profile
Involved external institutions
Guangzhou Medical University (GMU) / 广州医科大学
China (CN)
Shanxi Datong University (SDU) / 山西大同大学
China (CN)
National Cancer Institute of Ukraine / Національний інститут раку
Ukraine (UA)
Trakia University
Bulgaria (BG)
Finnish Institute for Molecular Medicine (FIMM) / Suomen Molekyylilääketieteen Instituutti
Finland (FI)
China (CN)
Shanxi Datong University (SDU) / 山西大同大学
China (CN)
National Cancer Institute of Ukraine / Національний інститут раку
Ukraine (UA)
Trakia University
Bulgaria (BG)
Finnish Institute for Molecular Medicine (FIMM) / Suomen Molekyylilääketieteen Instituutti
Finland (FI)
How to cite
APA:
Fan, X.Y., Deng, Z.F., Yan, Y.Y., E Orel, V., Shypko, A., B Orel, V.,... Zhang, J.Y. (2022). Application of microfluidic chips in anticancer drug screening. Bosnian Journal of Basic Medical Sciences, 22(3), 302-314. https://dx.doi.org/10.17305/bjbms.2021.6484
MLA:
Fan, Xin Yue, et al. "Application of microfluidic chips in anticancer drug screening." Bosnian Journal of Basic Medical Sciences 22.3 (2022): 302-314.
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