Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration

Canales DA, Reyes F, Saavedra M, Peponi L, Leonés A, Palza H, Boccaccini AR, Grünewald A, Zapata PA (2022)

Publication Type: Journal article

Publication year: 2022

Journal

International Journal of Biological Macromolecules Elsevier

Book Volume: 210

Pages Range: 324-336

DOI: 10.1016/j.ijbiomac.2022.05.047

Abstract

Electrospun fibers of poly (lactic acid) (PLA) containing 10 and 20 wt% of bioactive glass (n-BG) and magnesium oxide (n-MgO) nanoparticles of ca. 27 and 23 nm respectively, were prepared toward to application in bone tissue engineering. The addition of both nanoparticles into the PLA will produce a synergic effect increasing its bioactivity and antimicrobial behavior. Neat PLA scaffold and the composites with MgO showed an average fiber diameter of 1.7 ± 0.6 μm, PLA/n-BG and PLA/n-BG/n-MgO fibers presented a significant diameter increase reaching values of ca. 3.1 ± 0.8 μm. Young's modulus of the electrospun scaffolds was affected by the direct presence of the particle and scaffold morphologies. All the composites having n-BG presented bioactivity through the precipitation of hydroxyapatite structures on the surface. Although n-MgO did not add bioactivity to the PLA fibers, they were able to render antimicrobial characteristics reducing the S. aureus viability around 30%, although an effect on E. coli strain was not observed. PLA/n-BG nanocomposites did not display any significant antimicrobial behavior. The different composites increased the alkaline phosphatase (ALP) expression as compared with pure PLA barely affecting the cell viability, meaning a good osteoblastic phenotype expression capacity, with PLA/n-BG presenting the highest osteoblastic expression.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Alina Grünewald Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidad de Santiago de Chile (USACH) / University of Santiago, Chile CL Chile (CL) Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC) ES Spain (ES) Universidad de Chile CL Chile (CL)

How to cite

APA:

Canales, D.A., Reyes, F., Saavedra, M., Peponi, L., Leonés, A., Palza, H.,... Zapata, P.A. (2022). Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration. International Journal of Biological Macromolecules, 210, 324-336. https://doi.org/10.1016/j.ijbiomac.2022.05.047

MLA:

Canales, Daniel A., et al. "Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration." International Journal of Biological Macromolecules 210 (2022): 324-336.

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