Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients

Fichte A, Neumann AD, Weigelt K, Guzman J, Jansen T, Keinert J, Serrero G, Yue B, Stöhr R, Greither T, Hartmann A, Wullich B, Taubert H, Wach S, Lieb V (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Life MDPI

Book Volume: 12

Article Number: 732

Journal Issue: 5

DOI: 10.3390/life12050732

Abstract

Our study aimed to assess the applicability of miR-486 in combination with soluble GP88 protein as a diagnostic and/or predictive biomarker for prostate cancer (PCa) patients. miR-486 and GP88 levels in serum samples from 136 patients undergoing MRI-guided biopsy of the prostate were assessed by qRT–PCR and ELISA, respectively. Of these, 86 patients received a histologically confirmed diagnosis of PCa. Neither marker showed an association with the diagnosis of cancer. PCa patients were separated based on (i) treatment into patients with active surveillance or patients with any type of curative treatment and (ii) age into elderly (>68 years) patients and younger patients (≤68 years). In elderly patients (N = 41) with the intention of curative treatment at optimized cut-off values, significantly higher GP88 levels (p = 0.018) and lower miR-486 levels (p = 0.014) were observed. The total PSA level and ISUP biopsy grade were used in a baseline model for predicting definitive therapy. The baseline model exhibited an area under the curve (AUC) of 0.783 (p = 0.005). The addition of the serum biomarkers miR-486 and GP88 to the baseline model yielded an improved model with an AUC of 0.808 (p = 0.002). Altogether, combined miR-486 and GP88 serum levels are associated with and are therefore suggested as supportive biomarkers for therapy decisions, particularly in elderly PCa patients.

Authors with CRIS profile

Alexander Fichte Urologische Klinik Anna-Dorothea Neumann Medizinische Fakultät Juan Guzman Galvan Urologische Klinik Thilo Jansen Medizinische Fakultät Julia Keinert Medizinische Fakultät Robert Stöhr Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Bernd Wullich Lehrstuhl für Urologie Helge Taubert Professur für Molekulare Urologie Sven Wach Medizinische Fakultät Verena Lieb Urologische Klinik

Involved external institutions

Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) University of Maryland Medical Center (UMMC) US United States (USA) (US) A&G Pharmaceutical US United States (USA) (US)

How to cite

APA:

Fichte, A., Neumann, A.-D., Weigelt, K., Guzman, J., Jansen, T., Keinert, J.,... Lieb, V. (2022). Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients. Life, 12(5). https://doi.org/10.3390/life12050732

MLA:

Fichte, Alexander, et al. "Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients." Life 12.5 (2022).

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