Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking

Kuth S, Karakaya E, Reiter N, Schmidt LP, Paulsen F, Tessmar J, Budday S, Boccaccini AR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Tissue Engineering - Part C: Methods Mary Ann Liebert Inc.

DOI: 10.1089/ten.tec.2022.0004

Abstract

Hydrogels are ideal materials for mimicking and engineering soft tissue. Hyaluronic acid is a linear polysaccharide native to the human extracellular matrix. In this study, we first develop and characterize two hydrogel compositions built from oxidized HA and gelatin with and without alginate-di-aldehyde (ADA) crosslinked by ionic and enzymatic agents with potential applications in soft tissue engineering and tissue mimicking structures. The stability under incubation conditions was improved by adjusting crosslinking times. Through large-strain mechanical measurements, the hydrogels' properties were compared to human brain tissue and the samples containing ADA revealed similar mechanical properties to the native tissue specimens in cyclic compression-tension. In vitro characterization demonstrated a high viability of encapsulated mouse embryonic fibroblasts and a spreading of the cells in case of ADA-free samples.

Authors with CRIS profile

Sonja Kuth Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Emine Karakaya Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Nina Reiter Lehrstuhl für Technische Mechanik (LTM) Lorenz-Peter Schmidt Lehrstuhl für Hochfrequenztechnik (LHFT) Friedrich Paulsen Lehrstuhl für Funktionelle und Klinische Anatomie Silvia Budday Lehrstuhl für Technische Mechanik (LTM) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Kuth, S., Karakaya, E., Reiter, N., Schmidt, L.-P., Paulsen, F., Tessmar, J.,... Boccaccini, A.R. (2022). Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking. Tissue Engineering - Part C: Methods. https://doi.org/10.1089/ten.tec.2022.0004

MLA:

Kuth, Sonja, et al. "Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking." Tissue Engineering - Part C: Methods (2022).

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