Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields.

Blumler P, Friedrich RP, Pereira J, Baun O, Alexiou C, Mailander V (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Nanotechnology, Science and Applications Dove Medical Press

Book Volume: 14

Pages Range: 91-100

DOI: 10.2147/NSA.S298003

Abstract

Controlled and contactless movements of magnetic nanoparticles are crucial for fundamental biotechnological and clinical research (eg, cell manipulation and sorting, hyperthermia, and magnetic drug targeting). However, the key technological question, how to generate suitable magnetic fields on various length scales (µm-m), is still unsolved. Here, we present a system of permanent magnets which allows for steering of iron oxide nanoparticles (SPIONs) on arbitrary trajectories observable by microscopy. The movement of the particles is simply controlled by an almost force-free rotation of cylindrical arrangements of permanent magnets. The same instrument can be used to move suspended cells loaded with SPIONs along with predetermined directions. Surprisingly, it also allows for controlled movements of intracellular compartments inside of individual cells. The exclusive use of permanent magnets simplifies scaled up versions for animals or even humans, which would open the door for remotely controlled in vivo guidance of nanoparticles or micro-robots.

Authors with CRIS profile

Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Max-Planck-Institut für Polymerforschung (MPI-P) / Max Planck Institute for Polymer Research DE Germany (DE)

How to cite

APA:

Blumler, P., Friedrich, R.P., Pereira, J., Baun, O., Alexiou, C., & Mailander, V. (2021). Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields. Nanotechnology, Science and Applications, 14, 91-100. https://doi.org/10.2147/NSA.S298003

MLA:

Blumler, Peter, et al. "Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields." Nanotechnology, Science and Applications 14 (2021): 91-100.

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