Expression of Prostate-specific Membrane Antigen (PSMA) in Papillary Renal Cell Carcinoma - Overview and Report on a Large Multicenter Cohort

Zschaebitz S, Erlmeier F, Stoehr C, Herrmann E, Polifka I, Agaimy A, Trojan L, Stroebel P, Becker F, Wuelfing C, Barth P, Stoeckle M, Staehler M, Stief C, Haferkamp A, Hohenfellner M, Macher-Goeppinger S, Wullich B, Noldus J, Brenner W, Roos FC, Walter B, Otto W, Burger M, Schrader AJ, Mondorf Y, Hartmann A, Ivanyi P, Steffens S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 13

Pages Range: 1706-1712

Journal Issue: 5

DOI: 10.7150/jca.63509

Abstract

Prostate specific membrane antigen (PSMA) is an emerging diagnostic and therapeutic target in prostate cancer. 68 Ga-PSMA-labeled hybrid imaging is used for the detection of prostate primary tumors and metastases. Therapeutic applications such as Lutetium-177 PSMA radionuclide therapy or bispecific antibodies that target PSMA are currently under investigation within clinical trials. The expression of PSMA, however, is not specific to prostate-tissue. It has been described in the neovascular endothelium of different types of cancer such as breast cancer, and clear cell renal cell carcinoma (ccRCC). The aim of this study was to analyze PSMA expression in papillary RCC (pRCC) type 1 and type 2, the most common non-ccRCC subtypes, and to evaluate the potential of PSMA-targeted imaging and treatment in pRCC. Formalin-fixed, paraffin-embedded tissue samples of primary tumors were analyzed for PSMA expression by immunohistochemistry. Out of n=374 pRCC specimens from the multicenter PANZAR consortium, n=197 pRCC type 1 and n=110 type 2 specimens were eligible for analysis and correlated with clinical data. In pRCC type 1 PSMA staining was positive in 4 of 197 (2.0%) samples whereas none (0/110) of the pRCC type 2 samples were positive for PSMA in this large cohort of pRCC patients. No significant PSMA expression was detected in pRCC. Reflecting current clinical evaluation of PMSA expression in RCC do not encourage further analysis in papillary subtypes.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Regensburg Germany (DE) Universitätsklinikum Münster Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Klinikum der Universität München (Großhadern und Innenstadt) Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Universitätsklinikum Göttingen Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE)

How to cite

APA:

Zschaebitz, S., Erlmeier, F., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2022). Expression of Prostate-specific Membrane Antigen (PSMA) in Papillary Renal Cell Carcinoma - Overview and Report on a Large Multicenter Cohort. Journal of Cancer, 13(5), 1706-1712. https://dx.doi.org/10.7150/jca.63509

MLA:

Zschaebitz, Stefanie, et al. "Expression of Prostate-specific Membrane Antigen (PSMA) in Papillary Renal Cell Carcinoma - Overview and Report on a Large Multicenter Cohort." Journal of Cancer 13.5 (2022): 1706-1712.

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