Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Barone DG, Carnicer-Lombarte A, Tourlomousis P, Hamilton RS, Prater M, Rutz AL, Dimov IB, Malliaras GG, Lacour SP, Robertson AA, Franze K, Fawcett JW, Bryant CE (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences

Book Volume: 119

Pages Range: e2115857119

Journal Issue: 12

DOI: 10.1073/pnas.2115857119

Abstract

SignificanceImplantable electronic medical devices (IEMDs) are used for some clinical applications, representing an exciting prospect for the transformative treatment of intractable conditions such Parkinson's disease, deafness, and paralysis. The use of IEMDs is limited at the moment because, over time, a foreign body reaction (FBR) develops at the device-neural interface such that ultimately the IEMD fails and needs to be removed. Here, we show that macrophage nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity drives the FBR in a nerve injury model yet integration of an NLRP3 inhibitor into the device prevents FBR while allowing full healing of damaged neural tissue to occur.

Authors with CRIS profile

Kristian Franze Lehrstuhl für Medizinische Physik und Mikrogewebetechnik

Involved external institutions

École Polytechnique Fédérale de Lausanne (EPFL) CH Switzerland (CH) University of Cambridge GB United Kingdom (GB) University of Queensland AU Australia (AU)

How to cite

APA:

Barone, D.G., Carnicer-Lombarte, A., Tourlomousis, P., Hamilton, R.S., Prater, M., Rutz, A.L.,... Bryant, C.E. (2022). Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proceedings of the National Academy of Sciences of the United States of America, 119(12), e2115857119. https://dx.doi.org/10.1073/pnas.2115857119

MLA:

Barone, Damiano G., et al. "Prevention of the foreign body response to implantable medical devices by inflammasome inhibition." Proceedings of the National Academy of Sciences of the United States of America 119.12 (2022): e2115857119.

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