Friedrich AC, Linz P, Nagel AM, Rosenhauer D, Horn S, Schiffer M, Uder M, Kopp C, Dahlmann A (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 47
Pages Range: 185-193
Journal Issue: 3
DOI: 10.1159/000520821
BACKGROUND: The relationship between Na+ balance and cardiovascular disease (CVD) in hemodialysis (HD) patients is not yet fully understood. We hypothesized that HD patients co-diagnosed with CVD show increased tissue Na+ accumulation compared to HD patients without CVD. METHODS: In our observational study, 52 HD patients were divided into a group with (23 subjects) or without (29 subjects) a positive history of cardiovascular events. We used 23Na-magnetic resonance imaging (23Na-MRI) at 3.0 Tesla to quantify Na+ content in skin and muscle of both groups directly before and after HD. Additionally, total body fluid distribution was determined by bioimpedance spectroscopy (BIS) and laboratory parameters were assessed. RESULTS: Compared to HD patients without CVD, 23Na-MRI detected an increased Na+ content in skin (21.7 ± 7.3 vs. 30.2 ± 9.8 arbitrary units (a.u.), p < 0.01) and muscle tissue (21.5 ± 3.6 vs. 24.7 ± 6.0 a.u., p < 0.05) in patients with previous CVD events. Simultaneously measured fluid amount by BIS, includingexcess extracellular water (1.8 ± 1.7 vs. 2.2 ± 1.7 L, p = 0.44), was not significantly different between both groups. Tissue Na+ accumulation in HD-CVD patients was paralleled by a higher plasma concentration of the inflammation marker interleukin-6 (5.1, IQR 5.8 vs. 8.5, IQR 7.9 pg/mL, p < 0.05). CONCLUSION: In our cohort, HD patients with CVD showed higher tissue Na+ content than HD patients without CVD, while no difference in body water distribution could be detected between both groups. Our findings provide evidence that the history of a cardiovascular event is associated with disturbances in tissue Na+ content in HD patients.
APA:
Friedrich, A.C., Linz, P., Nagel, A.M., Rosenhauer, D., Horn, S., Schiffer, M.,... Dahlmann, A. (2022). Hemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition. Kidney & Blood Pressure Research, 47(3), 185-193. https://doi.org/10.1159/000520821
MLA:
Friedrich, Anna Carolina, et al. "Hemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition." Kidney & Blood Pressure Research 47.3 (2022): 185-193.
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