Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD?
Lechner K, Zeeshan M, Noack M, Ali H, Neurath M, Weigmann B (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
DOI: 10.1080/17425247.2022.2043847
Abstract
Introduction: Inflammatory bowel disease (IBD) is the inflammatory condition of the gastrointestinal tract particularly affecting the colon and the ileum. IBD patients can have a very poor quality of life because of the limited therapeutic efficacy and accompanied adverse effects. Areas covered: The potential ways to employ nanoparticles to deliver drugs to a certain site of inflammation are discussed. The focus was set on the microenvironment in the gut as well as the mucosa, epithelial layer and the microbiota. Moreover, experimental animal colitis models were nanoparticles were used as a potential treatment are presented. Lastly, challenges for the potential clinical use in humans are discussed. Expert opinion: Although there still remain many open questions e.g. regarding the toxicity, the metabolism or the pharmacokinetics of nanoparticles further research on this topic could overcome these challenges. For example, instead of synthetically engineered particles, biodegradable components could be used. Since there have been a lot pf promising results in the recent years, we are sure that in the future nanoparticles will be developed in a way to ensure safe and targeted delivery of drugs to the site of inflammation.
Authors with CRIS profile
Kristina Lechner-Grimm
Lehrstuhl für Genetik
Maxi Noack
Medizinische Fakultät
Markus Neurath
Lehrstuhl für Innere Medizin I
Benno Weigmann
Medizinische Fakultät
Related research project(s)
Involved external institutions
Pakistan (PK)How to cite
APA:
Lechner, K., Zeeshan, M., Noack, M., Ali, H., Neurath, M., & Weigmann, B. (2022). Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD? Expert Opinion on Drug Delivery. https://doi.org/10.1080/17425247.2022.2043847
MLA:
Lechner, Kristina, et al. "Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD?" Expert Opinion on Drug Delivery (2022).
BibTeX: Download