Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Maloca PM, Feu-Basilio S, Schottenhamml J, Valmaggia P, Scholl HP, Rosinés-Fonoll J, Marin-Martinez S, Inglin N, Reich M, Lange C, Egan C, Zweifel S, Tufail A, Spaide RF, Zarranz-Ventura J (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 12

Pages Range: 3695-

Journal Issue: 1

DOI: 10.1038/s41598-022-07439-2

Abstract

Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.

Authors with CRIS profile

Julia Schottenhamml Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Institute of Molecular and Clinical Ophthalmology Basel CH Switzerland (CH) Hospital Clínic de Barcelona ES Spain (ES) Universitätsklinikum Freiburg DE Germany (DE) Moorfields Eye Hospital NHS Foundation Trust GB United Kingdom (GB) Universitätsspital Zürich (USZ) CH Switzerland (CH) Retina-Vitreous Associates Medical Group US United States (USA) (US)

How to cite

APA:

Maloca, P.M., Feu-Basilio, S., Schottenhamml, J., Valmaggia, P., Scholl, H.P., Rosinés-Fonoll, J.,... Zarranz-Ventura, J. (2022). Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography. Scientific Reports, 12(1), 3695-. https://dx.doi.org/10.1038/s41598-022-07439-2

MLA:

Maloca, Peter M., et al. "Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography." Scientific Reports 12.1 (2022): 3695-.

BibTeX: Download