The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors
Jasinski-Bergner S, Eckstein M, Taubert H, Wach S, Fiebig C, Strick R, Hartmann A, Seliger B (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 13
Pages Range: 811200-
DOI: 10.3389/fimmu.2022.811200
Abstract
The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein involved in the induction of immunological tolerance. This is based on the binding of membrane-bound as well as soluble HLA-G to inhibitory receptors expressed on various immune effector cells, in particular NK cells and T cells, leading to their attenuated functions. Despite its restricted expression on immune-privileged tissues under physiological conditions, HLA-G expression has been frequently detected in solid and hematopoietic malignancies including urological cancers, such as renal cell and urothelial bladder carcinoma and has been associated with progression of urological cancers and poor outcome of patients: HLA-G expression protects tumor cells from anti-tumor immunity upon interaction with its inhibitory receptors by modulating both the phenotype and function of immune cells leading to immune evasion. This review will discuss the expression, regulation, functional and clinical relevance of HLA-G expression in urological tumors as well as its use as a putative biomarker and/or potential therapeutic target for the treatment of renal cell carcinoma as well as urothelial bladder cancer.
Authors with CRIS profile
Markus Eckstein
Institute of Pathology
Helge Taubert
Professur für Molekulare Urologie
Sven Wach
Medizinische Fakultät
Christian Fiebig
Urologische Klinik
Reiner Strick
Medizinische Fakultät
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Involved external institutions
Germany (DE)How to cite
APA:
Jasinski-Bergner, S., Eckstein, M., Taubert, H., Wach, S., Fiebig, C., Strick, R.,... Seliger, B. (2022). The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors. Frontiers in Immunology, 13, 811200-. https://dx.doi.org/10.3389/fimmu.2022.811200
MLA:
Jasinski-Bergner, Simon, et al. "The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors." Frontiers in Immunology 13 (2022): 811200-.
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