Iterative Cross-Scanner Registration for Whole Slide Images

Theelke L, Wilm F, Marzahl C, Bertram CA, Klopfleisch R, Maier A, Aubreville M, Breininger K (2021)

Publication Type: Conference contribution

Publication year: 2021

Publisher: IEEE COMPUTER SOC

City/Town: LOS ALAMITOS

Pages Range: 582-590

Conference Proceedings Title: 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021)

DOI: 10.1109/ICCVW54120.2021.00071

Abstract

The successful registration of digitized microscopic images is required for many applications in digital pathology. In particular, the registration of specimens scanned by different slide scanning systems may be beneficial to transfer expert annotations from one image domain to another and thereby reduce labeling effort. We present an iterative approach to register microscopic specimens digitized with multiple scanning systems, aiming to compute an optimal global transformation for the images at highest resolution. For this purpose, an initial registration based on a down-scaled version of the images is followed by a patch-based iterative update scheme. We make use of the hierarchical structure of digitized whole slide images to gradually approximate the optimal transformation. By using kernel density estimation to weight local transformation estimates, the influence of registration errors can be further mitigated. We validate our method on five histologic and five cytologic samples, each scanned with four different scanning systems. Furthermore, we perform first experiments on samples stained with different stain combinations. Our experiments demonstrate the potential of the proposed method for a variety of datasets and application fields.

Authors with CRIS profile

Involved external institutions

Technische Hochschule Ingolstadt Germany (DE) Stiftung Tierärztliche Hochschule Hannover (TiHo) Germany (DE) Freie Universität Berlin Germany (DE)

How to cite

APA:

Theelke, L., Wilm, F., Marzahl, C., Bertram, C.A., Klopfleisch, R., Maier, A.,... Breininger, K. (2021). Iterative Cross-Scanner Registration for Whole Slide Images. In 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021) (pp. 582-590). LOS ALAMITOS: IEEE COMPUTER SOC.

MLA:

Theelke, Luisa, et al. "Iterative Cross-Scanner Registration for Whole Slide Images." Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCVW) LOS ALAMITOS: IEEE COMPUTER SOC, 2021. 582-590.

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