Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses

Frech M, Omata Y, Schmalzl A, Wirtz S, Taher L, Schett G, Zaiss M, Sarter K (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

DOI: 10.3389/fimmu.2022.757436

Abstract

Innate lymphoid cells (ILC) not only are responsible for shaping the innate immune response but also actively modulate T cell responses. However, the molecular processes regulating ILC-T cell interaction are not yet completely understood. The protein butyrophilin 2a2 (Btn2a2), a co-stimulatory molecule first identified on antigen-presenting cells, has a pivotal role in the maintenance of T cell homeostasis, but the main effector cell and the respective ligands remain elusive. We analyzed the role of Btn2a2 in the ILC-T cell cross talk. We found that the expression of Btn2a2 is upregulated in ILC2 following stimulation with IL-33/IL-25/TSLP. In vitro and in vivo experiments indicated that lack of Btn2a2 expression on ILC2 resulted in elevated T cell responses. We observed an enhanced proliferation of T cells as well as increased secretion of the type 2 cytokines IL-4/IL-5/IL-13 following cocultures with Btn2a2-deficient ILC2. In vivo transfer experiments confirmed the regulatory role of Btn2a2 on ILC2 as Btn2a2-deficient ILC2 induced stronger T cell responses and prevented chronic helminth infections. Taken together, we identified Btn2a2 as a significant player in the regulation of ILC2-T cell interactions.

Authors with CRIS profile

Michael Frech Department of Medicine 3 – Rheumatology and Immunology Angelika Schmalzl Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Stefan Wirtz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Georg Schett Lehrstuhl für Innere Medizin III Mario Zaiss Department of Medicine 3 – Rheumatology and Immunology Kerstin Sarter-Zaiss Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Technische Universität Graz AT Austria (AT)

How to cite

APA:

Frech, M., Omata, Y., Schmalzl, A., Wirtz, S., Taher, L., Schett, G.,... Sarter, K. (2022). Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses. Frontiers in Immunology, 13. https://dx.doi.org/10.3389/fimmu.2022.757436

MLA:

Frech, Michael, et al. "Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses." Frontiers in Immunology 13 (2022).

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