Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI

Kamp B, Frenken M, Henke JM, Abrar DB, Nagel AM, Gast L, Oeltzschner G, Wilms LM, Nebelung S, Antoch G, Wittsack HJ, Mueller-Lutz A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Diagnostics MDPI

Book Volume: 11

Journal Issue: 12

DOI: 10.3390/diagnostics11122301

Abstract

Sodium MRI has the potential to depict cartilage health accurately, but synovial fluid can influence the estimation of sodium parameters of cartilage. Therefore, this study aimed to reduce the impact of synovial fluid to render the quantitative compositional analyses of cartilage tissue technically more robust. Two dedicated protocols were applied for determining sodium T-1 and T-2* relaxation times. For each protocol, data were acquired from 10 healthy volunteers and one patient with patellar cartilage damage. Data recorded with multiple repetition times for T-1 measurement and multi-echo data acquired with an additional inversion recovery pulse for T-2* measurement were analysed using biexponential models to differentiate longitudinal relaxation components of cartilage (T-1,T-car) and synovial fluid (T-1,T-syn), and short (T-2s*) from long (T-2l*) transversal relaxation components. Sodium relaxation times and concentration estimates in patellar cartilage were successfully determined: T-1,T-car = 14.5 & PLUSMN; 0.7 ms; T-1,T-syn = 37.9 & PLUSMN; 2.9 ms; c(T-1-protocol) = 200 & PLUSMN; 48 mmol/L; T-2s* = 0.4 & PLUSMN; 0.1 ms; T-2l* = 12.6 & PLUSMN; 0.7 ms; c(T-2*-protocol) = 215 & PLUSMN; 44 mmol/L for healthy volunteers. In conclusion, a robust determination of sodium relaxation times is possible at a clinical field strength of 3T to quantify sodium concentrations, which might be a valuable tool to determine cartilage health.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung Lena Gast Institute of Radiology

Involved external institutions

Heinrich-Heine-Universität Düsseldorf DE Germany (DE) Johns Hopkins University (JHU) US United States (USA) (US)

How to cite

APA:

Kamp, B., Frenken, M., Henke, J.M., Abrar, D.B., Nagel, A.M., Gast, L.,... Mueller-Lutz, A. (2021). Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI. Diagnostics, 11(12). https://dx.doi.org/10.3390/diagnostics11122301

MLA:

Kamp, Benedikt, et al. "Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI." Diagnostics 11.12 (2021).

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