SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications

Friedrich RP, Janko C, Unterweger H, Lyer S, Alexiou C (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Physical Sciences Review De Gruyter

DOI: 10.1515/psr-2019-0093

Abstract

In the past decades, a wide variety of different superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized. Due to their unique properties, such as big surface-to-volume ratio, superparamagnetism and comparatively low toxicity, they are principally well suited for many different technical and biomedical applications. Meanwhile, there are a numerous synthesis methods for SPIONs, but high requirements for biocompatibility have so far delayed a successful translation into the clinic. Moreover, depending on the planned application, such as for imaging, magnetic drug targeting, hyperthermia or for hybrid materials intended for regenerative medicine, specific physicochemical and biological properties are inevitable. Since a summary of all existing SPION systems, their properties and application is far too extensive, this review reports on selected methods for SPION synthesis, their biocompatibility and biomedical applications.

Authors with CRIS profile

Christina Janko Einrichtungen, die zum Universitätsklinikum Erlangen gehören Harald Unterweger Department of Otorhinolaryngology – Head and Neck Surgery Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin

How to cite

APA:

Friedrich, R.P., Janko, C., Unterweger, H., Lyer, S., & Alexiou, C. (2021). SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications. Physical Sciences Review. https://dx.doi.org/10.1515/psr-2019-0093

MLA:

Friedrich, Ralf P., et al. "SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications." Physical Sciences Review (2021).

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