Thermodynamics-based design of microbial cell factories for anaerobic product formation
Cueto-Rojas HF, Van Maris AJA, Heijnen JJ, Wahl SA (2015)
Publication Type: Journal article, Review article
Publication year: 2015
Journal
Book Volume: 33
Pages Range: 534-546
Journal Issue: 9
DOI: 10.1016/j.tibtech.2015.06.010
Abstract
The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates.
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Netherlands (NL)How to cite
APA:
Cueto-Rojas, H.F., Van Maris, A.J.A., Heijnen, J.J., & Wahl, S.A. (2015). Thermodynamics-based design of microbial cell factories for anaerobic product formation. Trends in Biotechnology, 33(9), 534-546. https://dx.doi.org/10.1016/j.tibtech.2015.06.010
MLA:
Cueto-Rojas, Hugo F., et al. "Thermodynamics-based design of microbial cell factories for anaerobic product formation." Trends in Biotechnology 33.9 (2015): 534-546.
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