Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models

Herrmann L, Hahn F, Wangen C, Marschall M, Tsogoeva S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

DOI: 10.1002/chem.202103861

Abstract

The presently ongoing pandemic of human SARS-CoV-2 infections (COVID-19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline-morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture-based inhibitory profile against SARS-CoV-2. Thus, selected quinoline compounds may suggest specific hit-to-lead development.

Authors with CRIS profile

Lars Herrmann Lehrstuhl für Organische Chemie I Friedrich Hahn Professur für Virologie Manfred Marschall Lehrstuhl für Klinische und Molekulare Virologie Svetlana Tsogoeva Professur für Organische Chemie

How to cite

APA:

Herrmann, L., Hahn, F., Wangen, C., Marschall, M., & Tsogoeva, S. (2021). Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models. Chemistry - A European Journal. https://dx.doi.org/10.1002/chem.202103861

MLA:

Herrmann, Lars, et al. "Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models." Chemistry - A European Journal (2021).

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