Effect of Sr, Mg and Fe substitution on the physico-chemical and biological properties of Si[sbnd]Ca[sbnd]P multilayer scaffolds Efecto de la sustitución de Sr, Mg y Fe en las propiedades físico-químicas y biológicas de andamios multicapa de Si-Ca-P

Mata NA, Arango Ospina M, Velasquez P, Murciano A, De Aza PN, Boccaccini AR (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Boletin De La Sociedad Espanola De Ceramica Y Vidrio Consejo Superior de Investigaciones Cientificas

DOI: 10.1016/j.bsecv.2021.11.005

Abstract

In this work, a new combination of ceramic materials is proposed for bone tissue engineering applications. Multilayer scaffolds consisting of a core composed mainly of calcium pyrophosphate and external coatings of silica and calcium doped with Fe3+, Sr2+ and Mg2+ were prepared. To study the influence of the arrangement of dopant ions in the external coatings, two different scaffolds were developed: scaffolds 3J consisting of a single external coating with 9 mol% of Fe3+, Sr2+ and Mg2+ ions; and scaffolds 3S comprising three external coatings, each containing 3 mol% of Fe3+, Sr2+ and Mg2+ ions. Scaffolds were physico-chemically characterized and evaluated for in vitro bioactivity and cellular response in the presence of MG-63 cells. The results showed that the core scaffold displayed no in vitro bioactivity or good cellular response, but served as a support for the external coatings given its mechanical resistance. The cell viability of scaffolds 3J and 3S increased more than 100% in relation to the core, and also improved cell proliferation and adhesion resulting in a dense layer of cells that covered the scaffolds’ entire surface. The arrangement of ions in the external coatings did not influence the cellular response, but determined the bioactivity rate.

Authors with CRIS profile

Marcela Arango Ospina Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Miguel Hernández University of Elche (UMH) / Universidad Miguel Hernández de Elche ES Spain (ES)

How to cite

APA:

Mata, N.A., Arango Ospina, M., Velasquez, P., Murciano, A., De Aza, P.N., & Boccaccini, A.R. (2021). Effect of Sr, Mg and Fe substitution on the physico-chemical and biological properties of Si[sbnd]Ca[sbnd]P multilayer scaffolds Efecto de la sustitución de Sr, Mg y Fe en las propiedades físico-químicas y biológicas de andamios multicapa de Si-Ca-P. Boletin De La Sociedad Espanola De Ceramica Y Vidrio. https://dx.doi.org/10.1016/j.bsecv.2021.11.005

MLA:

Mata, Nayarit A., et al. "Effect of Sr, Mg and Fe substitution on the physico-chemical and biological properties of Si[sbnd]Ca[sbnd]P multilayer scaffolds Efecto de la sustitución de Sr, Mg y Fe en las propiedades físico-químicas y biológicas de andamios multicapa de Si-Ca-P." Boletin De La Sociedad Espanola De Ceramica Y Vidrio (2021).

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