The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival

Vitali F, Wein A, Rath T, Eckstein M, Neufert C, Siebler J, Atreya R, Hartmann A, Hohenberger W, Weber K, Neurath M, Grützmann R, Merkel S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

International Journal of Colorectal Disease Springer Verlag

DOI: 10.1007/s00384-021-04072-9

Abstract

Purpose Patients with inflammatory bowel disease (IBD) have an increased risk for colorectal cancer (CRC). In IBD patients, cancer is often diagnosed in advanced stages and conflicting data on survival compared to sporadic CRC have been reported. The aim of this study was to directly compare clinical characteristics and prognosis of patients with IBD-CRC and sporadic CRC. Methods The clinical and pathological data of 63 patients with IBD-CRC and 3710 patients with sporadic CRC treated at the University Hospital of Erlangen between 1995 and 2015 were compared. Forty-seven M0 patients with IBD were matched with sporadic CRC patients after curative resection (R0) according to tumor localization, stage, sex, and year of treatment. Overall and disease-free survival were compared. Results Sixty-three patients presented IBD-CRC. Fifty were affected with ulcerative colitis (UC) and 13 with Crohn's disease (CD). CRC was diagnosed within 1.45 years since last endoscopic surveillance. Twelve patients (19%) had a diagnosis of primary sclerosing cholangitis. In matched analysis, IBD patients were diagnosed with CRC at younger age compared to sporadic CRC and were more likely to have right-sided CRC (40% versus 23.3%) and rare histological subtypes (19% versus 9.2%). No differences in 5-year overall (78.7 versus 80.9 months) and 5-year disease-free survival (74.5 versus 70.2 months) were noted. Conclusion IBD-CRC patients were younger and more frequently had right-sided carcinomas compared to sporadic CRC. CRC in IBD patients did not show survival difference compared to matched-pair sporadic CRC patients without distant metastases after curative resection. Surveillance might be important for early detection of CRC in IBD patients.

Authors with CRIS profile

Francesco Vitali Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Axel Wein Medizinische Fakultät Timo Rath Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Eckstein Institute of Pathology Clemens Neufert Medizinische Fakultät Jürgen Siebler Professur für Hepatologie Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Werner Hohenberger Lehrstuhl für Allgemein- und Viszeralchirurgie Markus Neurath Lehrstuhl für Innere Medizin I Robert Grützmann Lehrstuhl für Allgemein- und Viszeralchirurgie Susanne Merkel Department of Surgery

How to cite

APA:

Vitali, F., Wein, A., Rath, T., Eckstein, M., Neufert, C., Siebler, J.,... Merkel, S. (2021). The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival. International Journal of Colorectal Disease. https://dx.doi.org/10.1007/s00384-021-04072-9

MLA:

Vitali, Francesco, et al. "The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival." International Journal of Colorectal Disease (2021).

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