Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients

Regensburger A, Wagner A, Danko V, Jüngert JM, Federle A, Klett D, Schüssler S, Buehler A, Neurath M, Roos A, Lochmüller H, Wölfle J, Trollmann R, Waldner M, Knieling F (2022)

Publication Language: English

Publication Type: Journal article

Publication year: 2022

Journal

Photoacoustics Elsevier

Book Volume: 25

Article Number: 100315

DOI: 10.1016/j.pacs.2021.100315

Open Access Link: https://www.sciencedirect.com/science/article/pii/S2213597921000744

Abstract

Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a novel non-invasive imaging approach to visualize and quantify muscle wasting in pediatric SMA. While MSOT signals were distributed homogeneously in muscles of healthy volunteers (HVs), SMA patients showed moth-eaten optoacoustic signal patterns. Further signal quantification revealed greatest differences between groups at the isosbestic point for hemoglobin (SWL 800 nm). The SWL 800 nm signal intensities further correlated with clinical phenotype tested by standard motor outcome measures. Therefore, handheld MSOT could enable non-invasive assessment of disease burden in SMA patients.

Authors with CRIS profile

Adrian Regensburger Department of Paediatrics and Adolescent Medicine Alexandra Wagner Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie Anna Federle Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Daniel Klett Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Stephanie Schüssler Department of Paediatrics and Adolescent Medicine Markus Neurath Lehrstuhl für Innere Medizin I Joachim Wölfle Lehrstuhl für Kinder- und Jugendmedizin Regina Trollmann Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie Maximilian Waldner Lehrstuhl für Innere Medizin I Ferdinand Knieling Department of Paediatrics and Adolescent Medicine

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

J089: Multispectral optoacoustic tomography for non invasive characterization of strictures in Crohn’s disease Jan. 1, 2021 - March 31, 2024

Involved external institutions

University of Ottawa CA Canada (CA) Universität Duisburg-Essen (UDE) DE Germany (DE)

How to cite

APA:

Regensburger, A., Wagner, A., Danko, V., Jüngert, J.M., Federle, A., Klett, D.,... Knieling, F. (2022). Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients. Photoacoustics, 25. https://dx.doi.org/10.1016/j.pacs.2021.100315

MLA:

Regensburger, Adrian, et al. "Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients." Photoacoustics 25 (2022).

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