There is strength in numbers: Quantitation of Fc gamma receptors on murine tissue-resident macrophages

Vorsatz C, Friedrich N, Nimmerjahn F, Biburger M (2021)


Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 22

Article Number: 12172

Journal Issue: 22

URI: https://www.mdpi.com/1422-0067/22/22/12172

DOI: 10.3390/ijms222212172

Open Access Link: https://www.mdpi.com/1422-0067/22/22/12172

Abstract

Many of the effector functions of antibodies rely on the binding of antibodies/immune complexes to cellular Fcγ receptors (FcγRs). Since the majority of innate immune effector cells express both activating and inhibitory Fc receptors, the outcome of the binding of immune complexes to cells of a given population is influenced by the relative affinities of the respective IgG subclasses to these receptors, as well as by the numbers of activating and inhibitory FcγRs on the cell surface. A group of immune cells that has come into focus more recently is the various subsets of tissue-resident macrophages. The central functions of FcγRs on tissue macrophages include the clearance of opsonized pathogens, the removal of small immune complexes from the circulation and the depletion of antibody-opsonized cells in the therapy of autoimmunity and cancer. Despite these essential functions of FcγRs on tissue-resident macrophages, an in-depth quantification of FcγRs is lacking. Thus, the aim of our current study was to quantify the various Fcγ receptors on macrophages in murine liver, lung, kidney, brain, skin and spleen. Our study identified a pronounced heterogeneity between FcγR expression patterns of the different tissue macrophages, which may reflect their specialized functions within their unique niches in different organ environments.

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How to cite

APA:

Vorsatz, C., Friedrich, N., Nimmerjahn, F., & Biburger, M. (2021). There is strength in numbers: Quantitation of Fc gamma receptors on murine tissue-resident macrophages. International Journal of Molecular Sciences, 22(22). https://dx.doi.org/10.3390/ijms222212172

MLA:

Vorsatz, Christof, et al. "There is strength in numbers: Quantitation of Fc gamma receptors on murine tissue-resident macrophages." International Journal of Molecular Sciences 22.22 (2021).

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