Protein induced lipid demixing in homogeneous membranes

Stumpf H, Nowakowski P, Eggeling C, Maciolek A, Smith AS (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Physical Review Research American Physical Society

Book Volume: 3

Journal Issue: 4

DOI: 10.1103/PhysRevResearch.3.L042013

Abstract

Specific lipid environments are necessary for the establishment of protein signaling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model of protein induced local demixing of lipid membranes. The coupling between a local composition and a local thickness of the membrane induces lipid domains around inclusions with hydrophobic mismatch, even for temperatures above the miscibility critical point of the membrane. The model qualitatively explains the experimentally observed formation of lipid domains induced by anchoring of reconstituted actin in flat supported lipid bilayers.

Authors with CRIS profile

Henning Stumpf Physics Underlying Life Science Ana-Suncana Smith Physics Underlying Life Science

Involved external institutions

Friedrich-Schiller-Universität Jena DE Germany (DE) Max Planck Institute for Intelligent Systems (MPI-IS) / Max-Planck-Institut für Intelligente Systeme DE Germany (DE)

How to cite

APA:

Stumpf, H., Nowakowski, P., Eggeling, C., Maciolek, A., & Smith, A.-S. (2021). Protein induced lipid demixing in homogeneous membranes. Physical Review Research, 3(4). https://dx.doi.org/10.1103/PhysRevResearch.3.L042013

MLA:

Stumpf, Henning, et al. "Protein induced lipid demixing in homogeneous membranes." Physical Review Research 3.4 (2021).

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