Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications
Kurtuldu F, Kankova H, Beltrán AM, Liverani L, Galusek D, Boccaccini AR (2021)
Publication Type: Journal article, Original article
Publication year: 2021
Journal
Original Authors: F. Kurtuldu, H. Kaňková, A.M. Beltrán, L. Liverani, D. Galusek, A.R. Boccaccini
Book Volume: 12
Pages Range: 100150
Article Number: 100150
DOI: 10.1016/j.mtbio.2021.100150
Abstract
Mesoporous bioactive glass nanoparticles (MBGNPs) are attracting significant attention as suitable materials for multifunctional biomedical applications. In this study, cerium was incorporated into MBGNPs using two different approaches. In the first approach, cerium was added to the glass system directly during the synthesis, while in the second approach, cerium was added to the as-synthesized MBGNPs via the template ion-exchange method. The influence of the method of synthesis on the physicochemical properties of nanoparticles was examined by SEM, TEM, XRD, FTIR, and N2 adsorption-desorption analyses. The MBGNPs exhibited spheroidal morphology and disordered mesoporous structure. XRD analysis confirmed the amorphous nature of the nanoparticles. The chemical composition was determined by the acid digestion method using ICP-OES. The influence of the synthesis method on the specific surface area, mesoporosity, and solubility of synthesized nanoparticles in Tris/HCl (pH 7.4) and acetate (pH 4.5) buffer has also been studied. The obtained Ce containing MBGNPs were non-cytotoxic toward preosteoblast MC3T3-E1 cells in contact with nanoparticles in a concentration of up to 100 μg/mL. The anti-inflammatory effect of Ce containing MBGNPs was tested with lipopolysaccharides (LPS)-induced proinflammatory RAW 264.7 macrophage cells. Ce containing MBGNPs decreased the release of nitric oxide, indicating the anti-inflammatory response of macrophage cells. Ce containing MBGNPs also showed antibacterial activity against S. aureus and E. coli. The mentioned features of the obtained MBGNPs make them useful in a variety of biomedical applications, considering their biocompatibility, anti-inflammatory response, and enhanced antibacterial effect.
Authors with CRIS profile
Fatih Kurtuldu
Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Trenčianska univerzita Alexandra Dubčeka v Trenčíne
Slovakia (SK)
University of Seville / Universidad de Sevilla
Spain (ES)
Slovakia (SK)
University of Seville / Universidad de Sevilla
Spain (ES)
How to cite
APA:
Kurtuldu, F., Kankova, H., Beltrán, A.M., Liverani, L., Galusek, D., & Boccaccini, A.R. (2021). Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications. Materials Today Bio, 12, 100150. https://dx.doi.org/10.1016/j.mtbio.2021.100150
MLA:
Kurtuldu, Fatih, et al. "Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications." Materials Today Bio 12 (2021): 100150.
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