Rapid Enrichment of Submicron Particles within a Spinning Droplet Driven by a Unidirectional Acoustic Transducer
Peng T, Fan C, Zhou M, Jiang F, Drummer D, Jiang B (2021)
Publication Type: Journal article
Publication year: 2021
Journal
DOI: 10.1021/acs.analchem.1c02914
Abstract
Efficient and rapid particle enrichment at the submicron scale is essential for research in biomedicine and biochemistry. Here, we demonstrate an acoustofluidic method for submicron particle enrichment within a spinning droplet driven by a unidirectional transducer. The unidirectional transducer generates intense sound energy with relatively low attenuation. Droplets placed offset in the wave propagation path on a polydimethylsiloxane film undergo strong pressure gradients, deforming into an ellipsoid shape and spinning at high speed. Benefitting from the drag force induced by the droplet spin and acoustic streaming and the radial force induced by the droplet compression and expansion, the submicron particles in the liquid droplet quickly enrich toward the central area following a spiral trajectory. Through numerical calculations and experimental processes, we have demonstrated the possible mechanism responsible for particle enrichment. The application of biological sample processing has also been exploited. This study anticipates that the strategy based on the spinning droplet and particle enrichment method will be highly desirable for many applications.
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China (CN)How to cite
APA:
Peng, T., Fan, C., Zhou, M., Jiang, F., Drummer, D., & Jiang, B. (2021). Rapid Enrichment of Submicron Particles within a Spinning Droplet Driven by a Unidirectional Acoustic Transducer. Analytical Chemistry. https://dx.doi.org/10.1021/acs.analchem.1c02914
MLA:
Peng, Tao, et al. "Rapid Enrichment of Submicron Particles within a Spinning Droplet Driven by a Unidirectional Acoustic Transducer." Analytical Chemistry (2021).
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