Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution
Ruhm L, Avdievich N, Ziegs T, Nagel AM, De Feyter HM, de Graaf RA, Henning A (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 244
Article Number: 118639
DOI: 10.1016/j.neuroimage.2021.118639
Abstract
Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
Authors with CRIS profile
Involved external institutions
Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics
Germany (DE)
Yale School of Medicine
United States (USA) (US)
Germany (DE)
Yale School of Medicine
United States (USA) (US)
How to cite
APA:
Ruhm, L., Avdievich, N., Ziegs, T., Nagel, A.M., De Feyter, H.M., de Graaf, R.A., & Henning, A. (2021). Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution. NeuroImage, 244. https://dx.doi.org/10.1016/j.neuroimage.2021.118639
MLA:
Ruhm, Loreen, et al. "Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution." NeuroImage 244 (2021).
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