Structural and functional properties of meprin β metalloproteinase with regard to cell signaling

Li W, Lueckstaedt W, Wöhner B, Bub S, Schulz A, Socher E, Arnold P (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Biochimica Et Biophysica Acta-Molecular Cell Research Elsevier

Original Authors: Wenjia Li, Wiebke Lückstädt, Birte Wöhner, Simon Bub, Antonia Schulz, Eileen Socher, Philipp Arnold

Pages Range: 119136

Article Number: 119136

DOI: 10.1016/j.bbamcr.2021.119136

Abstract

The metalloproteinase meprin β plays an important role during collagen I deposition in the skin, mucus detachment in the small intestine and also regulates the abundance of different cell surface proteins such as the interleukin-6 receptor (IL-6R), the triggering receptor expressed on myeloid cells 2 (TREM2), the cluster of differentiation 99 (CD99), the amyloid precursor protein (APP) and the cluster of differentiation 109 (CD109). With that, regulatory mechanisms that control meprin β activity and regulate its release from the cell surface to enable access to distant substrates are increasingly important. Here, we will summarize factors that alternate meprin β activity and thereby regulate its proteolytic activity on the cell surface or in the supernatant. We will also discuss cleavage of the IL-6R and TREM2 on the cell surface and compare it to CD109. CD109, as a substrate of meprin β, is cleaved within the protein core thereby releasing defined fragments from the cell surface. At last, we will also summarize the role of proteases in general and meprin β in particular in substrate release on extracellular vesicles.

Authors with CRIS profile

Wenjia Li Lehrstuhl für Funktionelle und Klinische Anatomie Simon Bub Department of Molecular Neurology Eileen Socher Lehrstuhl für Funktionelle und Klinische Anatomie Philipp Arnold Lehrstuhl für Funktionelle und Klinische Anatomie

Involved external institutions

Christian-Albrechts-Universität zu Kiel DE Germany (DE)

How to cite

APA:

Li, W., Lueckstaedt, W., Wöhner, B., Bub, S., Schulz, A., Socher, E., & Arnold, P. (2021). Structural and functional properties of meprin β metalloproteinase with regard to cell signaling. Biochimica Et Biophysica Acta-Molecular Cell Research, 119136. https://dx.doi.org/10.1016/j.bbamcr.2021.119136

MLA:

Li, Wenjia, et al. "Structural and functional properties of meprin β metalloproteinase with regard to cell signaling." Biochimica Et Biophysica Acta-Molecular Cell Research (2021): 119136.

BibTeX: Download