Bioactive Glass Flakes as Innovative Fillers in Chitosan Membranes for Guided Bone Regeneration

Zhang H, Wu J, Wan Y, Romeis S, Esper JD, Peukert W, Zheng K, Boccaccini AR (2021)

Publication Language: English

Publication Type: Journal article

Publication year: 2021

Journal

Advanced Engineering Materials Wiley

Article Number: 2101042

DOI: 10.1002/adem.202101042

Abstract

Herein, novel bioactive glass flakes (BGFs) (45S5 composition), obtained by compression in the liquid phase in a stirred media mill, are combined with chitosan (CS) to develop composite membranes using solvent casting for guided bone regeneration (GBR). The incorporation of BGFs endows CS membranes with superior bioactivity as evidenced by rapid hydroxyapatite formation after 3 days of immersion in simulated body fluid (SBF). Moreover, the addition of BGFs reduces the swelling ratio of CS membranes, beneficial for GBR applications. The swelling behavior can also be modulated by tuning the added amount of BGFs. In vitro cell studies indicate the noncytotoxicity of composite membranes toward osteoblast cell line MC3T3-E1, although the presence of BGFs slightly reduces the cell viability compared to pure CS membranes. The incorporation of BGFs also improves the osteogenic differentiation of MC3T3-E1 cells as indicated by the enhanced alkaline phosphatase activity. The results show the feasibility of BGFs as anisotropic bioactive fillers in polymeric matrices. In conclusion, the developed CS-BGF composite membranes show promising potential as a novel material for GBR.

Authors with CRIS profile

Huijun Zhang Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Stefan Romeis Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Julian Duane Esper Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Wolfgang Peukert Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Kai Zheng Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Additional Organisation(s)

Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden

Related research project(s)

Formsteuerung von Partikeln in einer Rührwerkskugelmühle May 1, 2021 - April 30, 2024

Involved external institutions

Huazhong University of Science & Technology CN China (CN)

How to cite

APA:

Zhang, H., Wu, J., Wan, Y., Romeis, S., Esper, J.D., Peukert, W.,... Boccaccini, A.R. (2021). Bioactive Glass Flakes as Innovative Fillers in Chitosan Membranes for Guided Bone Regeneration. Advanced Engineering Materials. https://dx.doi.org/10.1002/adem.202101042

MLA:

Zhang, Huijun, et al. "Bioactive Glass Flakes as Innovative Fillers in Chitosan Membranes for Guided Bone Regeneration." Advanced Engineering Materials (2021).

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