NEGATIVE VESSEL REMODELING IN STARGARDT DISEASE QUANTIFIED WITH VOLUME-RENDERED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Reich M, Dreesbach M, Boehringer D, Schottenhamml J, Gehring E, Scholl HP, Inglin N, Agostini H, Reinhard T, Lagrèze WA, Spaide RF, Lange C, Maloca PM (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Retina-The Journal of Retinal and Vitreous Diseases Lippincott, Williams & Wilkins

Book Volume: 41

Pages Range: 1948-1957

Journal Issue: 9

DOI: 10.1097/IAE.0000000000003110

Abstract

PURPOSE: To quantify retinal vasculature changes in Stargardt disease1 (STGD1) with volume-rendered optical coherence tomography angiography. METHODS: Optical coherence tomography angiography volumes from healthy subjects and two subgroups of patients with STGD1 with the presence/absence of definitely decreased autofluorescence areas were compared. Optical coherence tomography angiography vessel surface area and vessel volume were measured in central zones (Z) of 1-, 2-, and 3-mm diameter. RESULTS: Twenty nine eyes of 15 patients with STGD1 (20/9 eyes with/without definitely decreased autofluorescence) and 30 eyes of 15 controls contributed data. An enlarged foveal avascular zone was found in patients with STGD1 without and even more with definitely decreased autofluorescence associated with a vessel rarefication in central and also paracentral zones with unnoticeable autofluorescence. Vessel surface area and vessel volume were reduced in both STGD1 subgroups for all zones (P < 0.0001). Stargardt disease 1 eyes when compared to without definitely decreased autofluorescence showed reduced vessel surface area and vessel volume in Z2+3 (both P < 0.05). CONCLUSION: Volume rendering of optical coherence tomography angiography in STGD1 shows a reduced retinal flow in the central macula. This is most likely secondary to loss of neurosensory tissue with disease progression and therefore not likely be favorably influenced by gene transfer and retinal pigment epithelial transplantation. Retinal blood flow assessed by 3D volume-rendered optical coherence tomography angiography could serve as surrogate marker for vascular changes of the central retina.

Authors with CRIS profile

Julia Schottenhamml Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Institute of Molecular and Clinical Ophthalmology Basel CH Switzerland (CH) Universitätsklinikum Freiburg DE Germany (DE) Retina-Vitreous Associates Medical Group US United States (USA) (US)

How to cite

APA:

Reich, M., Dreesbach, M., Boehringer, D., Schottenhamml, J., Gehring, E., Scholl, H.P.,... Maloca, P.M. (2021). NEGATIVE VESSEL REMODELING IN STARGARDT DISEASE QUANTIFIED WITH VOLUME-RENDERED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina-The Journal of Retinal and Vitreous Diseases, 41(9), 1948-1957. https://dx.doi.org/10.1097/IAE.0000000000003110

MLA:

Reich, Michael, et al. "NEGATIVE VESSEL REMODELING IN STARGARDT DISEASE QUANTIFIED WITH VOLUME-RENDERED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY." Retina-The Journal of Retinal and Vitreous Diseases 41.9 (2021): 1948-1957.

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