Combined diffusion-relaxometry microstructure imaging: Current status and future prospects
Slator PJ, Palombo M, Miller KL, Westin CF, Laun FB, Kim D, Haldar JP, Benjamini D, Lemberskiy G, De Almeida Martins JP, Hutter J (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
DOI: 10.1002/mrm.28963
Abstract
Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, (Formula presented.), (Formula presented.), and (Formula presented.). This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.
Authors with CRIS profile
Involved external institutions
King’s College London
United Kingdom (GB)
Harvard University
United States (USA) (US)
New York University (NYU)
United States (USA) (US)
University College London (UCL)
United Kingdom (GB)
University of Southern California (USC)
United States (USA) (US)
Lund University / Lunds universitet
Sweden (SE)
University of Oxford
United Kingdom (GB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development
United States (USA) (US)
United Kingdom (GB)
Harvard University
United States (USA) (US)
New York University (NYU)
United States (USA) (US)
University College London (UCL)
United Kingdom (GB)
University of Southern California (USC)
United States (USA) (US)
Lund University / Lunds universitet
Sweden (SE)
University of Oxford
United Kingdom (GB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development
United States (USA) (US)
How to cite
APA:
Slator, P.J., Palombo, M., Miller, K.L., Westin, C.-F., Laun, F.B., Kim, D.,... Hutter, J. (2021). Combined diffusion-relaxometry microstructure imaging: Current status and future prospects. Magnetic Resonance in Medicine. https://dx.doi.org/10.1002/mrm.28963
MLA:
Slator, Paddy J., et al. "Combined diffusion-relaxometry microstructure imaging: Current status and future prospects." Magnetic Resonance in Medicine (2021).
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