Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease

Stürzl M, Kunz M, Krug SM, Naschberger E (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Frontiers in Medicine Frontiers Media

Book Volume: 8

Article Number: 643607

DOI: 10.3389/fmed.2021.643607

Abstract

Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the disease is rising. A major step in disease development is the breakdown of the epithelial cell barrier. Numerous blood vessels are directly located underneath this barrier. Diseased tissues are heavily vascularized and blood vessels significantly contribute to disease progression. The gut-vascular barrier (GVB) is an additional barrier controlling the entry of substances into the portal circulation and to the liver after passing the first epithelial barrier. The presence of the GVB rises the question, whether the vascular and endothelial barriers may communicate bi-directionally in the regulation of selective barrier permeability. Communication from epithelial to endothelial cells is well-accepted. In contrast, little is known on the respective backwards communication. Only recently, perfusion-independent angiocrine functions of endothelial cells were recognized in a way that endothelial cells release specific soluble factors that may directly act on the epithelial barrier. This review discusses the putative involvement of angiocrine inter-barrier communication in the pathogenesis of IBD.

Authors with CRIS profile

Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie Meik Kunz Lehrstuhl für Medizinische Informatik Elisabeth Naschberger Department of Surgery

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

Related research project(s)

D034: Role of fibroblast polarization in the pathogenesis of colorectal carcinoma May 1, 2020 - July 31, 2023

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Stürzl, M., Kunz, M., Krug, S.M., & Naschberger, E. (2021). Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.643607

MLA:

Stürzl, Michael, et al. "Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease." Frontiers in Medicine 8 (2021).

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