Magnetic 3D scaffolds for tissue engineering applications: bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles
Dittler ML, Zelis PM, Beltran AM, Destch R, Grillo CA, Gonzalez MC, Boccaccini AR (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 16
Journal Issue: 5
Abstract
Magnetic 45S5 bioactive glass (BG) based scaffolds covered with iron-loaded hydroxyapatite (Fe-HA-BG) nanoparticles were obtained and its cytotoxicity investigated. Fe-HA nanoparticles were synthesized by a wet chemical method involving the simultaneous addition of Fe2+/Fe3+ ions. BG based scaffolds were prepared by the foam replica procedure and covered with Fe-HA by dip-coating. Fe-HA-BG magnetic saturation values of 0.049 emu g(-1) and a very low remanent magnetization of 0.01 emu g(-1) were observed. The mineralization assay in simulated body fluid following Kokubo's protocol indicated that Fe-HA-BG scaffolds exhibited improved hydroxyapatite formation in comparison to uncoated scaffolds at shorter immersion times. The biocompatibility of the material in vitro was assessed using human osteoblast-like MG-63 cell cultures and mouse bone marrow-derived stroma cell line ST-2. Overall, the results herein discussed suggest that magnetic Fe-HA coatings seem to enhance the biological performance of 45S5 BG based scaffolds. Thus, this magnetic Fe-HA coated scaffold is an interesting system for bone tissue engineering applications and warrant further investigation.
Authors with CRIS profile
Involved external institutions
Universidad Tecnológica Nacional (UTN) / National Technological University
Argentina (AR)
University of Seville / Universidad de Sevilla
Spain (ES)
Argentina (AR)
University of Seville / Universidad de Sevilla
Spain (ES)
How to cite
APA:
Dittler, M.L., Zelis, P.M., Beltran, A.M., Destch, R., Grillo, C.A., Gonzalez, M.C., & Boccaccini, A.R. (2021). Magnetic 3D scaffolds for tissue engineering applications: bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles. Biomedical Materials, 16(5). https://dx.doi.org/10.1088/1748-605X/ac14cc
MLA:
Dittler, Maria Laura, et al. "Magnetic 3D scaffolds for tissue engineering applications: bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles." Biomedical Materials 16.5 (2021).
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