Association of prenatal alcohol exposure and prenatal maternal depression with offspring low-grade inflammation in early adolescence

Maschke J, Roetner J, Bösl S, Plank AC, Rohleder N, Goecke TW, Fasching P, Beckmann M, Kratz O, Moll G, Lenz B, Kornhuber J, Eichler A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

International Journal of Environmental Research and Public Health MDPI

Book Volume: 18

Article Number: 7920

Journal Issue: 15

DOI: 10.3390/ijerph18157920

Abstract

(1) This longitudinal study aimed to investigate the link between prenatal alcohol exposure and prenatal maternal depression with the offspring’s low-grade inflammatory status. (2) Prenatal alcohol exposure was determined via maternal self-report during the 3rd trimester of pregnancy (self-report+: n = 29) and the meconium alcohol metabolite Ethyl Glucuronide (EtG), collected at birth (≥30 ng/g: n = 23). The Edinburgh Postnatal Depression Scale (EPDS) was used to screen for prenatal maternal depressive symptoms during the 3rd trimester (≥10: n = 35). Fifteen years later, 122 adolescents (M = 13.32 years; 48.4% female) provided blood samples for the analysis of high sensitivity C-reactive protein (hsCRP; M = 0.91; SD = 1.28). (3) Higher hsCRP levels were found in EtG positive adolescents (p = 0.036, ηp² = 0.04) and an inverse non-significant dose–response relation with hsCRP (r = −0.35, p = 0.113). For maternal self-reported prenatal alcohol consumption (p = 0.780, ηp² = 0.00) and prenatal depressive symptoms (p = 0.360, ηp² = 0.01) no differences for hsCRP levels between the affected and unaffected groups were found. (4) Adolescents with prenatal alcohol exposure are at risk for low-grade systemic inflammation. The EtG biomarker may be more accurate compared to self-reports. The findings suggest that prenatal maternal depression does not evoke low-grade systemic inflammation.

Authors with CRIS profile

Janina Maschke Department of Child and Adolescent Mental Health Jakob Roetner Department of Child and Adolescent Mental Health Anne-Christine Plank Professur für Experimentelle Biomedizin Nicolas Rohleder Lehrstuhl für Gesundheitspsychologie Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Oliver Kratz Medizinische Fakultät Bernd Lenz Medizinische Fakultät Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Anna Eichler Department of Child and Adolescent Mental Health

How to cite

APA:

Maschke, J., Roetner, J., Bösl, S., Plank, A.-C., Rohleder, N., Goecke, T.W.,... Eichler, A. (2021). Association of prenatal alcohol exposure and prenatal maternal depression with offspring low-grade inflammation in early adolescence. International Journal of Environmental Research and Public Health, 18(15). https://doi.org/10.3390/ijerph18157920

MLA:

Maschke, Janina, et al. "Association of prenatal alcohol exposure and prenatal maternal depression with offspring low-grade inflammation in early adolescence." International Journal of Environmental Research and Public Health 18.15 (2021).

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