Treat me well or will resist: Uptake of mobile genetic elements determine the resistome of corynebacterium striatum
Leyton B, Ramos JN, Baio PVP, Veras JFC, Souza C, Burkovski A, Mattos-Guaraldi AL, Vieira VV, Abanto Marin M (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 22
Article Number: 7499
Journal Issue: 14
DOI: 10.3390/ijms22147499
Abstract
Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoro-quinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.
Authors with CRIS profile
Involved external institutions
University of the Frontier / Universidad de La Frontera (UFRO)
Chile (CL)
Oswaldo Cruz Foundation / Fundação Oswaldo Cruz (FIOCRUZ)
Brazil (BR)
Rio de Janeiro State University / Universidade do Estado do Rio de Janeiro (UERJ)
Brazil (BR)
Chile (CL)
Oswaldo Cruz Foundation / Fundação Oswaldo Cruz (FIOCRUZ)
Brazil (BR)
Rio de Janeiro State University / Universidade do Estado do Rio de Janeiro (UERJ)
Brazil (BR)
How to cite
APA:
Leyton, B., Ramos, J.N., Baio, P.V.P., Veras, J.F.C., Souza, C., Burkovski, A.,... Abanto Marin, M. (2021). Treat me well or will resist: Uptake of mobile genetic elements determine the resistome of corynebacterium striatum. International Journal of Molecular Sciences, 22(14). https://dx.doi.org/10.3390/ijms22147499
MLA:
Leyton, Benjamin, et al. "Treat me well or will resist: Uptake of mobile genetic elements determine the resistome of corynebacterium striatum." International Journal of Molecular Sciences 22.14 (2021).
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