SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system

Ittner E, Hartwig A, Elsesser O, Wüst H, Fröb F, Wedel M, Schimmel M, Tamm ER, Wegner M, Sock E (2021)

Publication Type: Journal article, Original article

Publication year: 2021

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 11

Article Number: 14044

Journal Issue: 1

DOI: 10.1038/s41598-021-93437-9

Abstract

The three SoxD proteins, Sox5, Sox6 and Sox13, represent closely related transcription factors with important roles during development. In the developing nervous system, SoxD proteins have so far been primarily studied in oligodendroglial cells and in interneurons of brain and spinal cord. In oligodendroglial cells, Sox5 and Sox6 jointly maintain the precursor state, interfere with terminal differentiation, and thereby ensure the proper timing of myelination in the central nervous system. Here we studied the role of SoxD proteins in Schwann cells, the functional counterpart of oligodendrocytes in the peripheral nervous system. We show that Schwann cells express Sox5 and Sox13 but not Sox6. Expression was transient and ceased with the onset of terminal differentiation. In mice with early Schwann cell-specific deletion of both Sox5 and Sox13, embryonic Schwann cell development was not substantially affected and progressed normally into the promyelinating stage. However, there was a mild and transient delay in the myelination of the peripheral nervous system of these mice. We therefore conclude that SoxD proteins—in stark contrast to their action in oligodendrocytes—promote differentiation and myelination in Schwann cells.

Authors with CRIS profile

Anna Hartwig Lehrstuhl für Biochemie und Pathobiochemie Olga Schaude Lehrstuhl für Biochemie und Pathobiochemie Hannah Wüst Lehrstuhl für Biochemie und Pathobiochemie Franziska Thiele Lehrstuhl für Biochemie und Pathobiochemie Miriam Wedel Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie Elisabeth Sock Medizinische Fakultät

Involved external institutions

Universität Regensburg DE Germany (DE)

How to cite

APA:

Ittner, E., Hartwig, A., Elsesser, O., Wüst, H., Fröb, F., Wedel, M.,... Sock, E. (2021). SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system. Scientific Reports, 11(1). https://dx.doi.org/10.1038/s41598-021-93437-9

MLA:

Ittner, Ella, et al. "SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system." Scientific Reports 11.1 (2021).

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