An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile

Hahn L, Karakaya E, Zorn T, Sochor B, Maier M, Stahlhut P, Forster S, Fischer K, Seiffert S, Pöppler AC, Detsch R, Luxenhofer R (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Biomacromolecules American Chemical Society

DOI: 10.1021/acs.biomac.1c00427

Abstract

Hydrogels are key components in several biomedical research areas such as drug delivery, tissue engineering, and biofabrication. Here, a novel ABA-type triblock copolymer comprising poly(2-methyl-2-oxazoline) as the hydrophilic A blocks and poly(2-phenethyl-2-oxazoline) as the aromatic and hydrophobic B block is introduced. Above the critical micelle concentration, the polymer self-assembles into small spherical polymer micelles with a hydrodynamic radius of approx 8-8.5 nm. Interestingly, this specific combination of hydrophilic and hydrophobic aromatic moieties leads to rapid thermoresponsive inverse gelation at polymer concentrations above a critical gelation concentration (20 wt %) into a macroporous hydrogel of densely packed micelles. This hydrogel exhibited pronounced viscoelastic solid-like properties, as well as extensive shear-thinning, rapid structure recovery, and good strain resistance properties. Excellent 3D-printability of the hydrogel at lower temperature opens a wide range of different applications, for example, in the field of biofabrication. In preliminary bioprinting experiments using NIH 3T3 cells, excellent cell viabilities of more than 95% were achieved. The particularly interesting feature of this novel material is that it can be used as a printing support in hybrid bioink systems and sacrificial bioink due to rapid dissolution at physiological conditions.

Authors with CRIS profile

Emine Karakaya Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Julius-Maximilians-Universität Würzburg DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE)

How to cite

APA:

Hahn, L., Karakaya, E., Zorn, T., Sochor, B., Maier, M., Stahlhut, P.,... Luxenhofer, R. (2021). An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile. Biomacromolecules. https://dx.doi.org/10.1021/acs.biomac.1c00427

MLA:

Hahn, Lukas, et al. "An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile." Biomacromolecules (2021).

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