Celiac disease: A challenging disease for pharmaceutical scientists
Matoori S, Fuhrmann G, Leroux JC (2013)
Publication Type: Journal article, Review article
Publication year: 2013
Journal
Book Volume: 30
Pages Range: 619-626
Journal Issue: 3
DOI: 10.1007/s11095-012-0951-x
Abstract
Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains that affects ~1% of the white ethnic population. In the last decades, a rise in prevalence of CD has been observed that cannot be fully explained by improved diagnostics. Genetic predisposition greatly influences the susceptibility of individuals towards CD, though environmental factors also play a role. With no pharmacological treatments available, the only option to keep CD in remission is a strict and permanent exclusion of dietary gluten. Such a gluten-free diet is difficult to maintain because of gluten's omnipresence in food (e.g., additive in processed food). The development of adjuvant therapies which would permit the intake of small amounts of gluten would be desirable to improve the quality of life of patients on a gluten-free diet. Such therapies include gluten-degrading enzymes, polymeric binders, desensitizing vaccines, anti-inflammatory drugs, transglutaminase 2 inhibitors, and HLA-DQ2 blockers. However, many of these approaches pose pharmaceutical challenges with respect to drug formulation and stability, or application route and dosing interval. This perspective article discusses how pharmaceutical scientists may deal with these challenges and contribute to the implementation of novel therapeutic options for patients with CD. © 2012 Springer Science+Business Media New York.
Authors with CRIS profile
Involved external institutions
Switzerland (CH)How to cite
APA:
Matoori, S., Fuhrmann, G., & Leroux, J.-C. (2013). Celiac disease: A challenging disease for pharmaceutical scientists. Pharmaceutical Research, 30(3), 619-626. https://dx.doi.org/10.1007/s11095-012-0951-x
MLA:
Matoori, Simon, Gregor Fuhrmann, and Jean-Christophe Leroux. "Celiac disease: A challenging disease for pharmaceutical scientists." Pharmaceutical Research 30.3 (2013): 619-626.
BibTeX: Download