Fabrication and characterization of cinnamaldehyde-loaded mesoporous bioactive glass nanoparticles/phbv-based microspheres for preventing bacterial infection and promoting bone tissue regeneration

Chotchindakun K, Pekkoh J, Ruangsuriya J, Zheng K, Ünalan I, Boccaccini AR (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Polymers MDPI

Book Volume: 13

Article Number: 1794

Journal Issue: 11

DOI: 10.3390/polym13111794

Abstract

Polyhydroxybutyrate-co-hydroxyvalerate (PHBV) is considered a suitable polymer for drug delivery systems and bone tissue engineering due to its biocompatibility and biodegradability. However, the lack of bioactivity and antibacterial activity hinders its biomedical applications. In this study, mesoporous bioactive glass nanoparticles (MBGN) were incorporated into PHBV to enhance its bioactivity, while cinnamaldehyde (CIN) was loaded in MBGN to introduce antimicro-bial activity. The blank (PHBV/MBGN) and the CIN-loaded microspheres (PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20) were fabricated by emulsion solvent extrac-tion/evaporation method. The average particle size and zeta potential of all samples were in-vestigated, as well as the morphology of all samples evaluated by scanning electron microscopy. PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20 significantly exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in the first 3 h, while CIN releasing behavior was observed up to 7 d. Human osteosarcoma cell (MG-63) proliferation and attachment were noticed after 24 h cell culture, demonstrating no adverse effects due to the presence of microspheres. Additionally, the rapid formation of hydroxyapatite on the composite microspheres after immersion in simulated body fluid (SBF) during 7 d revealed the bioactivity of the composite mi-crospheres. Our findings indicate that this system represents an alternative model for an antibacterial biomaterial for potential applications in bone tissue engineering.

Authors with CRIS profile

Kai Zheng Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Irem Ünalan Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Chiang Mai University (CMU) / มหาวิทยาลัยเชียงใหม่ TH Thailand (TH)

How to cite

APA:

Chotchindakun, K., Pekkoh, J., Ruangsuriya, J., Zheng, K., Ünalan, I., & Boccaccini, A.R. (2021). Fabrication and characterization of cinnamaldehyde-loaded mesoporous bioactive glass nanoparticles/phbv-based microspheres for preventing bacterial infection and promoting bone tissue regeneration. Polymers, 13(11). https://dx.doi.org/10.3390/polym13111794

MLA:

Chotchindakun, Kittipat, et al. "Fabrication and characterization of cinnamaldehyde-loaded mesoporous bioactive glass nanoparticles/phbv-based microspheres for preventing bacterial infection and promoting bone tissue regeneration." Polymers 13.11 (2021).

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