THz Detection of Biomolecules in Aqueous Environments-Status and Perspectives for Analysis Under Physiological Conditions and Clinical use

Weisenstein C, Wigger AK, Richter M, Sczech R, Boßerhoff AK, Bolivar PH (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Journal of Infrared, Millimeter, and Terahertz Waves Springer Verlag (Germany)

DOI: 10.1007/s10762-021-00792-9

Abstract

Bioanalytical THz sensing techniques have proven to be an interesting and viable tool for the label-free detection and analysis of biomolecules. However, a major challenge for THz bioanalytics is to perform investigations in the native aqueous environments of the analytes. This review recapitulates the status and future requirements for establishing THz biosensing as a complementary toolbox in the repertoire of standard bioanalytic methods. The potential use in medical research and clinical diagnosis is discussed. Under these considerations, this article presents a comprehensive categorization of biochemically relevant analytes that have been investigated by THz sensing techniques in aqueous media. The detectable concentration levels of ions, carbohydrates, (poly-)nucleotides, active agents, proteins and different biomacromolecules from THz experiments are compared to characteristic physiological concentrations and lower detection limits of state-of-the-art bioanalytical methods. Finally, recent experimental developments and achievements are discussed, which potentially pave the way for THz analysis of biomolecules under clinically relevant conditions.

Authors with CRIS profile

Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Universität Siegen DE Germany (DE)

How to cite

APA:

Weisenstein, C., Wigger, A.K., Richter, M., Sczech, R., Boßerhoff, A.K., & Bolivar, P.H. (2021). THz Detection of Biomolecules in Aqueous Environments-Status and Perspectives for Analysis Under Physiological Conditions and Clinical use. Journal of Infrared, Millimeter, and Terahertz Waves. https://dx.doi.org/10.1007/s10762-021-00792-9

MLA:

Weisenstein, Christian, et al. "THz Detection of Biomolecules in Aqueous Environments-Status and Perspectives for Analysis Under Physiological Conditions and Clinical use." Journal of Infrared, Millimeter, and Terahertz Waves (2021).

BibTeX: Download