Serum miRNAs Support the Indication for MRI-Ultrasound Fusion-Guided Biopsy of the Prostate in Patients with Low-PI-RADS Lesions

Keck B, Borkowetz A, Pöllmann J, Jansen T, Fischer M, Fuessel S, Kahlmeyer A, Wirth M, Huber J, Cavallaro AJ, Hammon M, Platzek I, Hartmann A, Baretton G, Kunath F, Sikic D, Taubert H, Wullich B, Erdmann K, Wach S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cells MDPI

Book Volume: 10

Journal Issue: 6

DOI: 10.3390/cells10061315

Abstract

Multiparametric MRI (mpMRI) and targeted biopsy of the prostate enhance the tumor detection rate. However, the prediction of clinically significant prostate cancer (PCa) is still limited. Our study tested the additional value of serum levels of selected miRNAs in combination with clinical and mpMRI information for PCa prediction and classification. A total of 289 patients underwent targeted mpMRI-ultrasound fusion-guided prostate biopsy complemented by systematic biopsy. Serum miRNA levels of miRNAs (miR-141, miR-375, miR-21-5p, miR-320b, miR-210-3p, let-7c, and miR-486) were determined by quantitative PCR. Detection of any PCa and of significant PCa were the outcome variables. The patient age, pre-biopsy PSA level, previous biopsy procedure, PI-RADS score, and serum miRNA levels were covariates for regularized binary logistic regression models. The addition of miRNA expression of miR-486 and let-7c to the baseline model, containing only clinical parameters, increased the predictive accuracy. Particularly in patients with PI-RADS ≤3, we determined a sensitivity for detecting significant PCa (Gleason score ≥ 7a corresponding to Grade group ≥2) of 95.2%, and an NPV for absence of significant PCa of 97.1%. This accuracy could be useful to support patient counseling in selected cases.

Authors with CRIS profile

Bastian Keck Medizinische Fakultät Julia Keinert Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Moritz Fischer Professur für Molekulare Urologie Alexander Josef Cavallaro Institute of Radiology Matthias Hammon Institute of Radiology Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Frank Kunath Urologische Klinik Helge Taubert Professur für Molekulare Urologie Bernd Wullich Lehrstuhl für Urologie Sven Wach Medizinische Fakultät

Involved external institutions

Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE)

How to cite

APA:

Keck, B., Borkowetz, A., Pöllmann, J., Jansen, T., Fischer, M., Fuessel, S.,... Wach, S. (2021). Serum miRNAs Support the Indication for MRI-Ultrasound Fusion-Guided Biopsy of the Prostate in Patients with Low-PI-RADS Lesions. Cells, 10(6). https://doi.org/10.3390/cells10061315

MLA:

Keck, Bastian, et al. "Serum miRNAs Support the Indication for MRI-Ultrasound Fusion-Guided Biopsy of the Prostate in Patients with Low-PI-RADS Lesions." Cells 10.6 (2021).

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