General and selective deoxygenation by hydrogen using a reusable earth-abundant metal catalyst

Schwob T, Kunnas P, De Jonge N, Papp C, Steinrück HP, Kempe R (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Science Advances American Association for the Advancement of Science

Book Volume: 5

Article Number: eaav3680

Journal Issue: 11

DOI: 10.1126/sciadv.aav3680

Abstract

Chemoselective deoxygenation by hydrogen is particularly challenging but crucial for an efficient late-stage modification of functionality-laden fine chemicals, natural products, or pharmaceuticals and the economic upgrading of biomass-derived molecules into fuels and chemicals. We report here on a reusable earth-abundant metal catalyst that permits highly chemoselective deoxygenation using inexpensive hydrogen gas. Primary, secondary, and tertiary alcohols as well as alkyl and aryl ketones and aldehydes can be selectively deoxygenated, even when part of complex natural products, pharmaceuticals, or biomass-derived platform molecules. The catalyst tolerates many functional groups including hydrogenation-sensitive examples. It is efficient, easy to handle, and conveniently synthesized from a specific bimetallic coordination compound and commercially available charcoal. Selective, sustainable, and cost-efficient deoxygenation under industrially viable conditions seems feasible.

Authors with CRIS profile

Christian Papp Lehrstuhl für Physikalische Chemie II Hans-Peter Steinrück Lehrstuhl für Physikalische Chemie II

Involved external institutions

Universität Bayreuth DE Germany (DE) Leibniz-Institut für Neue Materialien gGmbH / Leibniz Institute for New Materials (INM) DE Germany (DE)

How to cite

APA:

Schwob, T., Kunnas, P., De Jonge, N., Papp, C., Steinrück, H.-P., & Kempe, R. (2019). General and selective deoxygenation by hydrogen using a reusable earth-abundant metal catalyst. Science Advances, 5(11). https://doi.org/10.1126/sciadv.aav3680

MLA:

Schwob, T., et al. "General and selective deoxygenation by hydrogen using a reusable earth-abundant metal catalyst." Science Advances 5.11 (2019).

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