Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity

Kurtuldu F, Mutlu N, Michálek M, Zheng K, Masar M, Liverani L, Chen S, Galusek D, Boccaccini AR (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 124

Article Number: 112050

DOI: 10.1016/j.msec.2021.112050

Abstract

In recent years, mesoporous bioactive glass nanoparticles (MBGNPs) have generated great attention in biomedical applications. In this study, cerium and gallium doped MBGNPs were prepared by microemulsion assisted sol-gel method in the binary SiO2-CaO system. MBGNPs with spheroidal and pineal shaped morphology were obtained. Nitrogen sorption analysis elucidated the mesoporous structure of synthesized nanoparticles with high specific surface area. X-ray diffraction analysis confirmed the amorphous nature of the nanoparticles. The chemical compositions of all samples were determined by inductively coupled plasma-optical emission spectrometry (ICP-OES), which revealed that the contents of cerium and gallium could be tailored by adjusting the concentrations of the precursors used for the synthesis. All MBGNPs exhibited in vitro bioactivity when immersed in simulated body fluid, except the particles doped with higher amounts than 1 mol% of cerium. MBGNPs showed antibacterial activity against S. aureus and E. coli without exhibiting cytotoxicity towards MG-63 osteoblast-like cells. Mentioned features of the obtained Ce and Ga-doped MBGNPs make them useful for multifunctional applications such as drug delivery carriers or bioactive fillers for bone tissue engineering applications.

Authors with CRIS profile

Involved external institutions

Trenčianska univerzita Alexandra Dubčeka v Trenčíne Slovakia (SK) Tomas Bata University in Zlín (TBU) / Univerzita Tomáše Bati ve Zlíně (UTB) Czech Republic (CZ)

How to cite

APA:

Kurtuldu, F., Mutlu, N., Michálek, M., Zheng, K., Masar, M., Liverani, L.,... Boccaccini, A.R. (2021). Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity. Materials Science and Engineering C, 124. https://doi.org/10.1016/j.msec.2021.112050

MLA:

Kurtuldu, Fatih, et al. "Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity." Materials Science and Engineering C 124 (2021).

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